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Endocrine Abstracts

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ea0026oc5.3 | Hormone metabolism and action | ECE2011

Identification of melanocortin 2 receptor structures responsible for specific membrane expression and ACTH binding specificity

Fridmanis D , Petrovska R , Schioth H B , Klovins J

Membrane expression of ACTH receptor MC2R is specifically limited to adrenal cells. In addition, unlike the other members of the evolutionary related MCRs that recognize different melanocortin peptides, the MC2R solely binds ACTH. We used cassette substitutions and mutagenesis of individual amino acids for systematic construction of 30 chimeric and mutant MC2R/MC4R receptors to identify the receptor structures determining the selectivity of MC2R in membrane trafficking and ACT...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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